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KMID : 1004820110120030131
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Journal of Biomedical Research
2011 Volume.12 No. 3 p.131 ~ p.139
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Chemopreventive Effects of Red Ginseng on Colonic Aberrant Crypt Foci Induced by 1,2-Dimethylhydrazine (DMH)
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Kim Tae-Myoung
Shim Tae-Jin
Ryu Jae-Myun
Kim Dae-Joong
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Abstract
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The current study was designed to investigate the effect of Red ginseng extract on development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week old animals received subcutaneous injections of DMH (30 mg/kg body weight) four times, for a period of two weeks in order to induce ACF. The animals were divided into groups fed a diet containing red ginseng extract at three different doses (0.5, 1.0, and 2.0%), respectively. Animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF formation was observed in animals in the DMH-treated group. Four-time treatment with DMH induced mean 265.8±48.3 ACF/colon composed of a total of 608.8±110.9 aberrant crypts AC/colon. The numbers of ACF and AC induced by DMH were decreased to 204.4±29.3 and 464.7±70.3 by treatment with 0.5% red ginseng extract. In addition, the number of large ACF (≥4 AC/ACF) was suppressed from 39.9±10.6 ACF/colon in control to 28.5±5.3 ACF/colon in 0.5% red ginseng extract. These results suggested that red ginseng extract exerted a chemopreventive effect on DMH-induced colon cancer by inhibiting development of ACF and AC in F344 rats.
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KEYWORD
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Colon carcinogenesis, Red ginseng, 1,2-dimethylhydrazine (DMH), Aberrant crypt foci (ACF)
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